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Evidence is increasing that most addiction without exception is related to difficulty with the brain's reward center, particularly the mesolimbic system. This section of the problem regulates reward responses in acquiring food and sex, plus nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both when they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight naturally can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight-loss and the people who go through it one should err on the side of caution and let the FDA do its job and demand some investigation be done so the public understands the side effects and dangers of the medications before we drive them. Keep in mind that drug companies are in business to make money and that they would say almost anything to keep people on his or her medications.

Researchers found that participants taking this drug for a year, dropped a few pounds within 4 weeks and have kept the extra weight off during the entire 56 weeks from the study. Contrave is often a combination in the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which can be made up of more than one active ingredient, which might make them more efficient and safer.

Combo-pilling could be the newest fad or also the newest into the future under scrutiny and so it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is now popular is the fact that at the time of right now there aren't long term prescription slimming capsules that have been licensed by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be licensed by the FDA.

Seizures certainly are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug also can raise blood pressure and heartrate, and shouldn't be used in individuals with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure level and heartrate and must not be used in patients with uncontrolled high hypertension, along with by anyone with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients using a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients to the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking.

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